This paper describes some observations made following the prolonged administration of 20-methylcholanthrene to fourteen patients suffering from various tumors and one patient with polyp of the colon. Malignant growth consisted of six gastric cancers, and one each of malignant lymphoma, Ewing´s tumor, rectal cancer, fibrosarcoma, recurrent breast cancer, embryonal; cell cancer, recurrent leiomyosarcoma and recurrent seminoma.
In seven cases X-ray irradiation was combined and 8 patients showed regression of the tumor, ´ and in nine patients subjective therapeutic effect was significant. Five patient exhibited subjective and objective evidence of inhibition of malignant process, of which four patient recieved combined X-ray irradiation.
These inhibitory effects semed to be transitory in most cases with one exception that one patient with seminoma recovered and continued to be well for five years of observation period following: the cessation of treatment.
The intramuscular, administration of 20-methylcholanthrene gave, rise to little untoward effects except probably a marked decrease. in leucocyte counts of the peripheral blood in three patients.
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